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Administering low-dose intravenous ketamine transforms multimodal general anesthesia by targeting central pain pathways before surgical stimulation begins. Ketamine functions as a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, dampening dorsal horn wind-up and preventing acute central sensitization (Peltoniemi et al., 2016). When combined synergistically with gamma-aminobutyric acid (GABA) receptor agonists like propofol, it produces reliable hypnotic depth and somatic analgesia
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We all know propofol and ketamine… but in anesthesia, we often combine them into something even better: Ketofol. Ketofol = ketamine propofol given together IV to provide both sedation AND pain control during procedures. Here’s why that matters 👇 🧠 Ketamine → provides strong pain relief dissociation (you’re not aware of the procedure) 😴 Propofol → gives deep relaxation sleepiness ⚖️ When combined, they balance each other’s effects: • More stable sedation • Less discomfort • Potentially fewer s
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